Publications

@article{phillips2020high,

title = {High-throughput fluorescence microscopy using multi-frame motion deblurring},

author = { Zachary F Phillips and Sarah Dean and Benjamin Recht and Laura Waller},

url = {https://doi.org/10.1364/BOE.11.000281},

doi = {10.1364/BOE.11.000281},

year  = {2019},

date = {2019-12-16},

journal = {Biomedical Optics Express},

volume = {11},

number = {1},

pages = {281--300},

publisher = {Optical Society of America},

keywords = {deconvolution, fluorescence imaging, high-throughput, motion deblur},

pubstate = {published},

tppubtype = {article}

}

@article{yeh2019speckle,

title = {Speckle-structured illumination for 3D phase and fluorescence computational microscopy},

author = { Li-Hao Yeh and Shwetadwip Chowdhury and Nicole A Repina and Laura Waller},

url = {https://doi.org/10.1364/BOE.10.003635},

doi = {10.1364/BOE.10.003635},

year  = {2019},

date = {2019-07-01},

journal = {Biomedical optics express},

volume = {10},

number = {7},

pages = {3635--3653},

publisher = {Optical Society of America},

keywords = {3D imaging, high-throughput, multiple-scattering, speckle},

pubstate = {published},

tppubtype = {article}

}

@article{pinkard2019deep,

title = {Deep learning for single-shot autofocus microscopy},

author = { Henry Pinkard and Zachary F Phillips and Arman Babakhani and Daniel A Fletcher and Laura Waller},

url = {https://www.osapublishing.org/optica/abstract.cfm?uri=optica-6-6-794},

year  = {2019},

date = {2019-06-20},

journal = {Optica},

volume = {6},

number = {6},

pages = {794--797},

publisher = {Optical Society of America},

keywords = {algorithms, high-throughput, LED array},

pubstate = {published},

tppubtype = {article}

}

@article{yeh2019computational,

title = {Computational structured illumination for high-content fluorescence and phase microscopy},

author = { Li-Hao Yeh and Shwetadwip Chowdhury and Laura Waller},

url = {https://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-4-1978

https://doi.org/10.1364/BOE.10.001978},

doi = {10.1364/BOE.10.001978},

year  = {2019},

date = {2019-04-01},

journal = {Biomedical optics express},

volume = {10},

number = {4},

pages = {1978--1998},

publisher = {Optical Society of America},

abstract = {High-content biological microscopy targets high-resolution imaging across large fields-of-view (FOVs). Recent works have demonstrated that computational imaging can provide efficient solutions for high-content microscopy. Here, we use speckle structured illumination microscopy (SIM) as a robust and cost-effective solution for high-content fluorescence microscopy with simultaneous high-content quantitative phase (QP). This multi-modal compatibility is essential for studies requiring cross-correlative biological analysis. Our method uses laterally-translated Scotch tape to generate high-resolution speckle illumination patterns across a large FOV. Custom optimization algorithms then jointly reconstruct the sample’s super-resolution fluorescent (incoherent) and QP (coherent) distributions, while digitally correcting for system imperfections such as unknown speckle illumination patterns, system aberrations and pattern translations. Beyond previous linear SIM works, we achieve resolution gains of 4× the objective’s diffraction-limited native resolution, resulting in 700 nm fluorescence and 1.2 μm QP resolution, across a FOV of 2×2.7 mm 2, giving a space-bandwidth product (SBP) of 60 megapixels.},

keywords = {diffuser, fluorescence imaging, high-throughput, phase imaging, structured illumination, super-resolution},

pubstate = {published},

tppubtype = {article}

}

@article{yeh2015experimental,

title = {Experimental robustness of Fourier ptychography phase retrieval algorithms},

author = { Li-Hao Yeh and Jonathan Dong and Jingshan Zhong and Lei Tian and Michael Chen and Gongguo Tang and Mahdi Soltanolkotabi and Laura Waller},

url = {https://doi.org/10.1364/OE.23.033214},

doi = {10.1364/OE.23.033214},

year  = {2015},

date = {2015-12-16},

journal = {Optics express},

volume = {23},

number = {26},

pages = {33214--33240},

publisher = {Optical Society of America},

keywords = {algorithms, FPM, high-resolution, high-throughput, LED array, phase imaging},

pubstate = {published},

tppubtype = {article}

}

@article{tian2015computational,

title = {Computational illumination for high-speed in vitro Fourier ptychographic microscopy},

author = { Lei Tian and Ziji Liu and Li-Hao Yeh and Michael Chen and Jingshan Zhong and Laura Waller},

url = {https://doi.org/10.1364/OPTICA.2.000904},

doi = {10.1364/OPTICA.2.000904},

year  = {2015},

date = {2015-10-14},

journal = {Optica},

volume = {2},

number = {10},

pages = {904--911},

publisher = {Optical Society of America},

keywords = {FPM, high-resolution, high-throughput, in vitro imaging, LED array, phase imaging},

pubstate = {published},

tppubtype = {article}

}

@article{tian2014multiplexed,

title = {Multiplexed coded illumination for Fourier Ptychography with an LED array microscope},

author = { Lei Tian and Xiao Li and Kannan Ramchandran and Laura Waller},

url = {https://doi.org/10.1364/BOE.5.002376},

doi = {10.1364/BOE.5.002376},

year  = {2014},

date = {2014-06-19},

journal = {Biomedical optics express},

volume = {5},

number = {7},

pages = {2376--2389},

publisher = {Optical Society of America},

keywords = {algorithms, experimental design, FPM, high-resolution, high-throughput, LED array, multiplexed illumination},

pubstate = {published},

tppubtype = {article}

}