Journal papers
Yi Xue; Laura Waller; Hillel Adesnik; Nicolas Pégard
Three-dimensional multi-site random access photostimulation (3D-MAP) Journal Article
In: eLife, vol. 2022, no. 11, pp. e73266, 2022.
Links | BibTeX | Tags: 3D imaging
@article{Xue:2022,
title = {Three-dimensional multi-site random access photostimulation (3D-MAP)},
author = {Yi Xue and Laura Waller and Hillel Adesnik and Nicolas Pégard},
doi = {10.7554/eLife.73266},
year = {2022},
date = {2022-02-14},
journal = {eLife},
volume = { 2022},
number = {11},
pages = {e73266},
keywords = {3D imaging},
pubstate = {published},
tppubtype = {article}
}
Kyrollos Yanny; Kristina Monakhova; Richard W Shuai; Laura Waller
Deep learning for fast spatially varying deconvolution Journal Article
In: Optica, vol. 9, no. 1, pp. 96–99, 2022.
Abstract | Links | BibTeX | Tags: 3D imaging, Hyperspectral imaging; Image quality; Imaging systems; Neural networks; Reconstruction algorithms; Three dimensional reconstruction, spatially-varying
@article{Yanny:22,
title = {Deep learning for fast spatially varying deconvolution},
author = {Kyrollos Yanny and Kristina Monakhova and Richard W Shuai and Laura Waller},
url = {http://www.osapublishing.org/optica/abstract.cfm?URI=optica-9-1-96},
doi = {10.1364/OPTICA.442438},
year = {2022},
date = {2022-01-01},
journal = {Optica},
volume = {9},
number = {1},
pages = {96--99},
publisher = {OSA},
abstract = {Deconvolution can be used to obtain sharp images or volumes from blurry or encoded measurements in imaging systems. Given knowledge of the system's point spread function (PSF) over the field of view, a reconstruction algorithm can be used to recover a clear image or volume. Most deconvolution algorithms assume shift-invariance; however, in realistic systems, the PSF varies laterally and axially across the field of view due to aberrations or design. Shift-varying models can be used, but are often slow and computationally intensive. In this work, we propose a deep-learning-based approach that leverages knowledge about the system's spatially varying PSFs for fast 2D and 3D reconstructions. Our approach, termed MultiWienerNet, uses multiple differentiable Wiener filters paired with a convolutional neural network to incorporate spatial variance. Trained using simulated data and tested on experimental data, our approach offers a 625textminus1600texttimes increase in speed compared to iterative methods with a spatially varying model, and outperforms existing deep-learning-based methods that assume shift invariance.},
keywords = {3D imaging, Hyperspectral imaging; Image quality; Imaging systems; Neural networks; Reconstruction algorithms; Three dimensional reconstruction, spatially-varying},
pubstate = {published},
tppubtype = {article}
}
Kyrollos Yanny; Nick Antipa; William Liberti; Sam Dehaeck; Kristina Monakhova; Fanglin Linda Liu; Konlin Shen; Ren Ng; Laura Waller
Miniscope3D: optimized single-shot miniature 3D fluorescence microscopy Journal Article
In: Light: Science & Applications, vol. 9, no. 171, 2020.
Abstract | Links | BibTeX | Tags: 3D imaging, algorithms, diffuser, fluorescence imaging
@article{yanny2020,
title = {Miniscope3D: optimized single-shot miniature 3D fluorescence microscopy},
author = {Kyrollos Yanny and Nick Antipa and William Liberti and Sam Dehaeck and Kristina Monakhova and Fanglin Linda Liu and Konlin Shen and Ren Ng and Laura Waller},
url = {https://www.nature.com/articles/s41377-020-00403-7},
doi = {https://doi.org/10.1038/s41377-020-00403-7},
year = {2020},
date = {2020-10-02},
journal = {Light: Science & Applications},
volume = {9},
number = {171},
abstract = {Miniature fluorescence microscopes are a standard tool in systems biology. However, widefield miniature microscopes capture only 2D information, and modifications that enable 3D capabilities increase the size and weight and have poor resolution outside a narrow depth range. Here, we achieve the 3D capability by replacing the tube lens of a conventional 2D Miniscope with an optimized multifocal phase mask at the objective’s aperture stop. Placing the phase mask at the aperture stop significantly reduces the size of the device, and varying the focal lengths enables a uniform resolution across a wide depth range. The phase mask encodes the 3D fluorescence intensity into a single 2D measurement, and the 3D volume is recovered by solving a sparsity-constrained inverse problem. We provide methods for designing and fabricating the phase mask and an efficient forward model that accounts for the field-varying aberrations in miniature objectives. We demonstrate a prototype that is 17 mm tall and weighs 2.5 grams, achieving 2.76 μm lateral, and 15 μm axial resolution across most of the 900 × 700 × 390 μm3 volume at 40 volumes per second. The performance is validated experimentally on resolution targets, dynamic biological samples, and mouse brain tissue. Compared with existing miniature single-shot volume-capture implementations, our system is smaller and lighter and achieves a more than 2× better lateral and axial resolution throughout a 10× larger usable depth range. Our microscope design provides single-shot 3D imaging for applications where a compact platform matters, such as volumetric neural imaging in freely moving animals and 3D motion studies of dynamic samples in incubators and lab-on-a-chip devices.},
keywords = {3D imaging, algorithms, diffuser, fluorescence imaging},
pubstate = {published},
tppubtype = {article}
}
Michael Chen; David Ren; Hsiou-Yuan Liu; Shwetadwip Chowdhury; Laura Waller
Multi-layer Born multiple-scattering model for 3D phase microscopy Journal Article
In: Optica, vol. 7, no. 5, pp. 394–403, 2020.
Abstract | Links | BibTeX | Tags: 3D imaging, multiple-scattering, optical models, phase imaging
@article{Chen:20,
title = {Multi-layer Born multiple-scattering model for 3D phase microscopy},
author = {Michael Chen and David Ren and Hsiou-Yuan Liu and Shwetadwip Chowdhury and Laura Waller},
url = {http://www.osapublishing.org/optica/abstract.cfm?URI=optica-7-5-394},
doi = {10.1364/OPTICA.383030},
year = {2020},
date = {2020-05-01},
journal = {Optica},
volume = {7},
number = {5},
pages = {394--403},
publisher = {OSA},
abstract = {We propose an accurate and computationally efficient 3D scattering model, multi-layer Born (MLB), and use it to recover the 3D refractive index (RI) of thick biological samples. For inverse problems recovering the complex field of thick samples, weak scattering models (e.g., first Born) may fail or underestimate the RI, especially with a large index contrast. Multi-slice (MS) beam propagation methods model multiple scattering to provide more realistic reconstructions; however, MS does not properly account for highly oblique scattering, nor does it model backward scattering. Our proposed MLB model uses a first Born model at each of many slices, accurately capturing the oblique scattering effects and estimating the backward scattering process. When used in conjunction with an inverse solver, the model provides more accurate RI reconstructions for high-resolution phase tomography. Importantly, MLB retains a reasonable computation time that is critical for practical implementation with iterative inverse algorithms.},
keywords = {3D imaging, multiple-scattering, optical models, phase imaging},
pubstate = {published},
tppubtype = {article}
}
Grace Kuo; Fanglin Linda Liu; Irene Grossrubatscher; Ren Ng; Laura Waller
On-chip fluorescence microscopy with a random microlens diffuser Journal Article
In: Optics Express, vol. 28, no. 6, pp. 8384–8399, 2020.
Links | BibTeX | Tags: 3D imaging, diffuser, fluorescence imaging, lensless imaging, on-chip
@article{kuo2020chip,
title = {On-chip fluorescence microscopy with a random microlens diffuser},
author = { Grace Kuo and Fanglin Linda Liu and Irene Grossrubatscher and Ren Ng and Laura Waller},
url = {https://doi.org/10.1364/OE.382055},
doi = {10.1364/OE.382055},
year = {2020},
date = {2020-03-09},
journal = {Optics Express},
volume = {28},
number = {6},
pages = {8384--8399},
publisher = {Optical Society of America},
keywords = {3D imaging, diffuser, fluorescence imaging, lensless imaging, on-chip},
pubstate = {published},
tppubtype = {article}
}
David Ren; Colin Ophus; Michael Chen; Laura Waller
A multiple scattering algorithm for three dimensional phase contrast atomic electron tomography Journal Article
In: Ultramicroscopy, vol. 208, pp. 112860, 2020.
Links | BibTeX | Tags: 3D imaging, algorithms, multiple-scattering, phase imaging, TEM
@article{ren2020multiple,
title = {A multiple scattering algorithm for three dimensional phase contrast atomic electron tomography},
author = { David Ren and Colin Ophus and Michael Chen and Laura Waller},
url = {https://www.sciencedirect.com/science/article/pii/S030439911930052X},
year = {2020},
date = {2020-01-01},
journal = {Ultramicroscopy},
volume = {208},
pages = {112860},
publisher = {North-Holland},
keywords = {3D imaging, algorithms, multiple-scattering, phase imaging, TEM},
pubstate = {published},
tppubtype = {article}
}
Shwetadwip Chowdhury; Michael Chen; Regina Eckert; David Ren; Fan Wu; Nicole A Repina; Laura Waller
High-resolution 3D refractive index microscopy of multiple-scattering samples from intensity images Journal Article
In: Optica, vol. 6, no. 9, pp. 1211–1219, 2019.
Links | BibTeX | Tags: 3D imaging, multiple-scattering, phase imaging
@article{chowdhury2019high,
title = {High-resolution 3D refractive index microscopy of multiple-scattering samples from intensity images},
author = { Shwetadwip Chowdhury and Michael Chen and Regina Eckert and David Ren and Fan Wu and Nicole A Repina and Laura Waller},
url = {https://doi.org/10.1364/OPTICA.6.001211},
doi = {10.1364/OPTICA.6.001211},
year = {2019},
date = {2019-09-16},
journal = {Optica},
volume = {6},
number = {9},
pages = {1211--1219},
publisher = {Optical Society of America},
keywords = {3D imaging, multiple-scattering, phase imaging},
pubstate = {published},
tppubtype = {article}
}
Colin Ophus; David Ren; Jihan Zhou; Hannah Devyldere; Michael Chen; Philipp M Pelz; Peter Ercius; Jianwei Miao; Mary C Scott; Laura Waller
3D Imaging Using HAADF-STEM and HRTEM Atomic Electron Tomography Journal Article
In: Microscopy and Microanalysis, vol. 25, no. S2, pp. 394–395, 2019.
Links | BibTeX | Tags: 3D imaging, multiple-scattering, phase imaging, TEM
@article{ophus20193d,
title = {3D Imaging Using HAADF-STEM and HRTEM Atomic Electron Tomography},
author = { Colin Ophus and David Ren and Jihan Zhou and Hannah Devyldere and Michael Chen and Philipp M Pelz and Peter Ercius and Jianwei Miao and Mary C Scott and Laura Waller},
url = {https://doi.org/10.1017/S1431927619002708},
doi = {10.1017/S1431927619002708},
year = {2019},
date = {2019-08-05},
journal = {Microscopy and Microanalysis},
volume = {25},
number = {S2},
pages = {394--395},
publisher = {Cambridge University Press},
keywords = {3D imaging, multiple-scattering, phase imaging, TEM},
pubstate = {published},
tppubtype = {article}
}
Li-Hao Yeh; Shwetadwip Chowdhury; Nicole A Repina; Laura Waller
Speckle-structured illumination for 3D phase and fluorescence computational microscopy Journal Article
In: Biomedical optics express, vol. 10, no. 7, pp. 3635–3653, 2019.
Links | BibTeX | Tags: 3D imaging, high-throughput, multiple-scattering, speckle
@article{yeh2019speckle,
title = {Speckle-structured illumination for 3D phase and fluorescence computational microscopy},
author = { Li-Hao Yeh and Shwetadwip Chowdhury and Nicole A Repina and Laura Waller},
url = {https://doi.org/10.1364/BOE.10.003635},
doi = {10.1364/BOE.10.003635},
year = {2019},
date = {2019-07-01},
journal = {Biomedical optics express},
volume = {10},
number = {7},
pages = {3635--3653},
publisher = {Optical Society of America},
keywords = {3D imaging, high-throughput, multiple-scattering, speckle},
pubstate = {published},
tppubtype = {article}
}
Colin Ophus; David Ren; Michael Chen; Catherine Groschner; Mary C Scott; Laura Waller
Linear and Nonlinear Reconstruction Algorithms for Atomic-Resolution Tomography Using Phase Contrast Electron Microscopy Journal Article
In: Microscopy and Microanalysis, vol. 24, no. S1, pp. 110–111, 2018.
Links | BibTeX | Tags: 3D imaging, algorithms, phase imaging, TEM
@article{ophus2018linear,
title = {Linear and Nonlinear Reconstruction Algorithms for Atomic-Resolution Tomography Using Phase Contrast Electron Microscopy},
author = { Colin Ophus and David Ren and Michael Chen and Catherine Groschner and Mary C Scott and Laura Waller},
url = {https://doi.org/10.1017/S1431927618001046},
doi = {10.1017/S1431927618001046},
year = {2018},
date = {2018-08-01},
journal = {Microscopy and Microanalysis},
volume = {24},
number = {S1},
pages = {110--111},
publisher = {Cambridge University Press},
keywords = {3D imaging, algorithms, phase imaging, TEM},
pubstate = {published},
tppubtype = {article}
}
Alan R Mardinly; Ian Antón Oldenburg; Nicolas C Pégard; Savitha Sridharan; Evan H Lyall; Kirill Chesnov; Stephen G Brohawn; Laura Waller; Hillel Adesnik
Precise multimodal optical control of neural ensemble activity Journal Article
In: Nature neuroscience, vol. 21, no. 6, pp. 881–893, 2018.
Links | BibTeX | Tags: 3D imaging, digital holography, multiphoton, neural imaging
@article{mardinly2018precise,
title = {Precise multimodal optical control of neural ensemble activity},
author = { Alan R Mardinly and Ian Antón Oldenburg and Nicolas C Pégard and Savitha Sridharan and Evan H Lyall and Kirill Chesnov and Stephen G Brohawn and Laura Waller and Hillel Adesnik},
url = {https://doi.org/10.1038/s41593-018-0139-8},
doi = {10.1038/s41593-018-0139-8},
year = {2018},
date = {2018-04-30},
journal = {Nature neuroscience},
volume = {21},
number = {6},
pages = {881--893},
publisher = {Nature Publishing Group},
keywords = {3D imaging, digital holography, multiphoton, neural imaging},
pubstate = {published},
tppubtype = {article}
}
Nicolas C Pégard; Alan R Mardinly; Ian Antón Oldenburg; Savitha Sridharan; Laura Waller; Hillel Adesnik
Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT) Journal Article
In: Nature communications, vol. 8, no. 1, pp. 1–14, 2017.
Links | BibTeX | Tags: 3D imaging, digital holography, fluorescence imaging, neural imaging
@article{pegard2017three,
title = {Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT)},
author = { Nicolas C Pégard and Alan R Mardinly and Ian Antón Oldenburg and Savitha Sridharan and Laura Waller and Hillel Adesnik},
url = {https://doi.org/10.1038/s41467-017-01031-3},
doi = {10.1038/s41467-017-01031-3},
year = {2017},
date = {2017-10-31},
journal = {Nature communications},
volume = {8},
number = {1},
pages = {1--14},
publisher = {Nature Publishing Group},
keywords = {3D imaging, digital holography, fluorescence imaging, neural imaging},
pubstate = {published},
tppubtype = {article}
}
Jingzhao Zhang; Nicolas C Pégard; Jingshan Zhong; Hillel Adesnik; Laura Waller
3D computer-generated holography by non-convex optimization Journal Article
In: Optica, vol. 4, no. 10, pp. 1306–1313, 2017.
Links | BibTeX | Tags: 3D imaging, algorithms, digital holography, fluorescence imaging, neural imaging
@article{zhang20173d,
title = {3D computer-generated holography by non-convex optimization},
author = { Jingzhao Zhang and Nicolas C Pégard and Jingshan Zhong and Hillel Adesnik and Laura Waller},
url = {https://doi.org/10.1364/OPTICA.4.001306},
doi = {10.1364/OPTICA.4.001306},
year = {2017},
date = {2017-10-19},
journal = {Optica},
volume = {4},
number = {10},
pages = {1306--1313},
publisher = {Optical Society of America},
keywords = {3D imaging, algorithms, digital holography, fluorescence imaging, neural imaging},
pubstate = {published},
tppubtype = {article}
}
Hsiou-Yuan Liu; Jingshan Zhong; Laura Waller
Multiplexed phase-space imaging for 3D fluorescence microscopy Journal Article
In: Optics express, vol. 25, no. 13, pp. 14986–14995, 2017.
Links | BibTeX | Tags: 3D imaging, fluorescence imaging, phase space
@article{liu2017multiplexed,
title = {Multiplexed phase-space imaging for 3D fluorescence microscopy},
author = { Hsiou-Yuan Liu and Jingshan Zhong and Laura Waller},
url = {https://doi.org/10.1364/OE.25.014986},
doi = {10.1364/OE.25.014986},
year = {2017},
date = {2017-06-21},
journal = {Optics express},
volume = {25},
number = {13},
pages = {14986--14995},
publisher = {Optical Society of America},
keywords = {3D imaging, fluorescence imaging, phase space},
pubstate = {published},
tppubtype = {article}
}
Michael Chen; Lei Tian; Laura Waller
3D differential phase contrast microscopy Journal Article
In: Biomedical Optics Express, vol. 7, no. 10, pp. 3940–3950, 2016.
Links | BibTeX | Tags: 3D imaging, DPC, phase imaging
@article{chen20163d,
title = {3D differential phase contrast microscopy},
author = { Michael Chen and Lei Tian and Laura Waller},
url = {https://doi.org/10.1364/BOE.7.003940},
year = {2016},
date = {2016-10-01},
journal = {Biomedical Optics Express},
volume = {7},
number = {10},
pages = {3940--3950},
publisher = {Optical Society of America},
keywords = {3D imaging, DPC, phase imaging},
pubstate = {published},
tppubtype = {article}
}
Gili Dardikman; Mor Habaza; Laura Waller; Natan T Shaked
Video-rate processing in tomographic phase microscopy of biological cells using CUDA Journal Article
In: Optics express, vol. 24, no. 11, pp. 11839–11854, 2016.
Links | BibTeX | Tags: 3D imaging, algorithms
@article{dardikman2016video,
title = {Video-rate processing in tomographic phase microscopy of biological cells using CUDA},
author = { Gili Dardikman and Mor Habaza and Laura Waller and Natan T Shaked},
url = {https://doi.org/10.1364/OE.24.011839},
doi = {10.1364/OE.24.011839},
year = {2016},
date = {2016-05-23},
journal = {Optics express},
volume = {24},
number = {11},
pages = {11839--11854},
publisher = {Optical Society of America},
keywords = {3D imaging, algorithms},
pubstate = {published},
tppubtype = {article}
}
Hsiou-Yuan Liu; Eric Jonas; Lei Tian; Jingshan Zhong; Benjamin Recht; Laura Waller
3D imaging in volumetric scattering media using phase-space measurements Journal Article
In: Optics express, vol. 23, no. 11, pp. 14461–14471, 2015.
Links | BibTeX | Tags: 3D imaging, multiple-scattering, phase space
@article{liu20153d,
title = {3D imaging in volumetric scattering media using phase-space measurements},
author = { Hsiou-Yuan Liu and Eric Jonas and Lei Tian and Jingshan Zhong and Benjamin Recht and Laura Waller},
url = {https://doi.org/10.1364/OE.23.014461},
doi = {10.1364/OE.23.014461},
year = {2015},
date = {2015-05-22},
journal = {Optics express},
volume = {23},
number = {11},
pages = {14461--14471},
publisher = {Optical Society of America},
keywords = {3D imaging, multiple-scattering, phase space},
pubstate = {published},
tppubtype = {article}
}
Zachary F Phillips; Michael V D'Ambrosio; Lei Tian; Jared J Rulison; Hurshal S Patel; Nitin Sadras; Aditya V Gande; Neil A Switz; Daniel A Fletcher; Laura Waller
Multi-contrast imaging and digital refocusing on a mobile microscope with a domed LED array Journal Article
In: PloS one, vol. 10, no. 5, 2015.
Links | BibTeX | Tags: 3D imaging, CellScope, LED array, multi-contrast, phase imaging
@article{phillips2015multi,
title = {Multi-contrast imaging and digital refocusing on a mobile microscope with a domed LED array},
author = { Zachary F Phillips and Michael V D'Ambrosio and Lei Tian and Jared J Rulison and Hurshal S Patel and Nitin Sadras and Aditya V Gande and Neil A Switz and Daniel A Fletcher and Laura Waller},
url = {https://doi.org/10.1371/journal.pone.0124938
},
doi = {10.1371/journal.pone.0124938},
year = {2015},
date = {2015-05-13},
journal = {PloS one},
volume = {10},
number = {5},
publisher = {Public Library of Science},
keywords = {3D imaging, CellScope, LED array, multi-contrast, phase imaging},
pubstate = {published},
tppubtype = {article}
}
Lei Tian; Laura Waller
3D intensity and phase imaging from light field measurements in an LED array microscope Journal Article
In: optica, vol. 2, no. 2, pp. 104–111, 2015.
Links | BibTeX | Tags: 3D imaging, algorithms, FPM, LED array, light field
@article{tian20153db,
title = {3D intensity and phase imaging from light field measurements in an LED array microscope},
author = { Lei Tian and Laura Waller},
url = {https://doi.org/10.1364/OPTICA.2.000104},
doi = {10.1364/OPTICA.2.000104},
year = {2015},
date = {2015-01-28},
journal = {optica},
volume = {2},
number = {2},
pages = {104--111},
publisher = {Optical Society of America},
keywords = {3D imaging, algorithms, FPM, LED array, light field},
pubstate = {published},
tppubtype = {article}
}
Lei Tian; Jingyan Wang; Laura Waller
3D differential phase-contrast microscopy with computational illumination using an LED array Journal Article
In: Optics letters, vol. 39, no. 5, pp. 1326–1329, 2014.
Links | BibTeX | Tags: 3D imaging, DPC, LED array, phase imaging
@article{tian20143d,
title = {3D differential phase-contrast microscopy with computational illumination using an LED array},
author = { Lei Tian and Jingyan Wang and Laura Waller},
url = {https://doi.org/10.1364/OL.39.001326},
doi = {10.1364/OL.39.001326},
year = {2014},
date = {2014-02-28},
journal = {Optics letters},
volume = {39},
number = {5},
pages = {1326--1329},
publisher = {Optical Society of America},
keywords = {3D imaging, DPC, LED array, phase imaging},
pubstate = {published},
tppubtype = {article}
}